A Century of Alzheimer's Disease —Goedert 2006

This is an audio summary of the article "A Century of Alzheimer's Disease” by Goedert in 2006. A small group of psychiatrists first identified the abnormal protein deposits in the brain. This discovery defined the most common neurodegenerative disorders one hundred years ago. For the past 25 years, it has been clear that the proteins responsible for the deposits are essential for the development of sickness. Amyloid and tau combine to form filaments that mimic amyloid in the plaques and tangles of Alzheimer's disease. Tau inclusions are also seen in a number of related diseases. Genetic studies have shown that amyloid or tau-related dysfunction is enough to cause dementia. The continuing molecular examination of the neurodegenerative pathways is expected to give a full understanding of disease pathology.

Goedert, M., & Spillantini, M. G. (2006). A century of Alzheimer's disease. Science (New York, N.Y.), 314(5800), 777–781. https://doi.org/10.1126/science.1132814