Advances in Alzheimer's disease —Katzman 1991

This is an audio summary of the article "Advances in Alzheimer's disease" by Katzman in 1991. The mystery behind the origin of Alzheimer's disease remains unsolved. But during the last several years, we've learned a lot more about the illness and made progress in figuring out the molecular alterations that underlie the sickness. There is now strong proof that the loss of neurons and synapses, particularly in the neocortex and hippocampus, is what causes dementia per se. Both amyloid and its precursor protein's molecular characteristics have been established. It is starting to become clearer what intracellular modifications cause the paired helical filament to accumulate. Putative risk variables may now be explained in terms of pathogenetic pathways for the first time. Therefore, it could be conceivable in the not-too-distant future to find treatments that would halt the progression of this terrible illness. This is the end of this informational audio track on "Advances in Alzheimer's disease" by Katzman.

Katzman, R., & Saitoh, T. (1991). Advances in Alzheimer’s disease. The FASEB Journal, 5(3), 278–286. https://doi.org/10.1096/fasebj.5.3.2001787