Brief Review of Closed-Loop Control in Pediatric Diabetes Mellitus 1— Breton 2020

This is a brief audio review.

In the article A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes published, 2020 by Breton and Colleagues, The outcomes and key points are as noted: Closed loop systems resulted in greater amounts of time in the acceptable glycemic control range in type 1 diabetes mellitus pediatric patients when compared with patients on a continuous glucose sensor and separate insulin delivery system (sensor augmented system). 11 percentage point difference in glycemic control between closed loop systems and sensor augmented systems. P=/< 0.001, no significant differences in A1C -0.4 percentage points, P=0.08. In a Randomized controlled trial, open label (parallel group) with 101 patients who were Paediatric patients, 6-13 years old, with Diabetes Mellitus type 1.

This concludes the brief audio review of A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes published, 2020 by Breton and Colleagues.

Breton MD, Kanapka LG, Beck RW, Ekhlaspour L, Forlenza GP, Cengiz E, Schoelwer M, Ruedy KJ, Jost E, Carria L, Emory E, Hsu LJ, Oliveri M, Kollman CC, Dokken BB, Weinzimer SA, DeBoer MD, Buckingham BA, Cherñavvsky D, Wadwa RP; iDCL Trial Research Group. A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes. N Engl J Med. 2020 Aug 27;383(9):836-845. doi: 10.1056/NEJMoa2004736. PMID: 32846062; PMCID: PMC7920146.