Brief Review of Gene microarray analysis of human brain arteriovenous malformations— Hashimoto 2004

This is a brief audio review. In the article Gene microarray analysis of human brain arteriovenous malformations published, 2004 by Hashimoto and Colleagues, The outcomes and key points are as noted: Gene expression in brain tissue with arteriovenous malformations is distinct from control brain tissue samples, since there are increased gene expression levels for angiogenesis related molecules and increased levels of angiogenesis related protein. 6 brain tissue samples from patients with arteriovenous malformations and 5 control brain tissue samples were compared. 1781 out of 12625 tested gene probes showed increased expression in the arteriovenous malformations group, with an increased detection of messenger ribonucleic acid expression of vascular endothelial growth factor and increased expression of integrin alpha v' beta 3. This was a Observational, Case-control study, (of clinical pathologic specimens) with 11 brain tissue samples. 6 of these tissue samples were from patients with medically intractable seizure due to arteriovenous malformations.

Hashimoto T, Lawton MT, Wen G, Yang GY, Chaly T Jr, Stewart CL, Dressman HK, Barbaro NM, Marchuk DA, Young WL. Gene microarray analysis of human brain arteriovenous malformations. Neurosurgery. 2004 Feb;54(2):410-23; discussion 423-5. doi: 10.1227/01.neu.0000103421.35266.71. PMID: 14744289.