Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids — roque 2021

Idiopathic pulmonary fibrosis (IPF) is a lung condition that is progressive and chronic with no recognized cause. Alveolar epithelial cells are repeatedly damaged, and various signaling pathways are abnormally activated. According to recent research, the IPF lungs are characterized by metabolic reprogramming, metabolic dysregulation, and mitochondrial dysfunction. The aberrant collagen synthesis and dysregulated airway remodeling reported in lung fibrosis are caused by metabolomic anomalies in alveolar epithelial cells, myofibroblasts, macrophages, and fibroblasts. The metabolomic alterations in amino acids, lipids, glucose, and heme seen in IPF lungs are summarized in this study. By focusing on a number of metabolites, we also offer fresh insights into prospective therapeutic approaches.

Roque W, Romero F. Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids. Am J Physiol Cell Physiol. 2021 May 1;320(5):C689-C695. doi: 10.1152/ajpcell.00586.2020. Epub 2021 Jan 20. PMID: 33471621; PMCID: PMC8163573.