Mouse models of Intracranial Aneurysm — wang 2015

A subarachnoid hemorrhage that is lethal can result from an intracranial aneurysm rupture. Monitoring and surgery are currently used to treat aneurysms that have not ruptured. There is no medication that can reduce the likelihood of rupture, though. Drug interventions are now being investigated to reduce the likelihood of rupture. Researchers may be able to learn more about the progression of the disease by using mice with aneurysms. The review talks about the applicability of the mice models to human aneurysms. Additionally, it discusses how crucial these models are for understanding the disease's biological underpinnings. The essay concludes by examining potential pharmacological targets for the treatment of aneurysms. The renin-angiotensin system and the estrogen receptor are a couple of these targets. A common understanding of what an aneurysm is in the models would be beneficial for a better understanding of the disease and the application of findings to patients.

Wang, Y., Emeto, T. I., Lee, J., Marshman, L., Moran, C., Seto, S. W., & Golledge, J. (2015). Mouse models of intracranial aneurysm. Brain pathology (Zurich, Switzerland), 25(3), 237–247. https://doi.org/10.1111/bpa.12175