Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design—Zolla-Pazner 2010

HIV's antigenic diversity makes it difficult to elicit immunological responses for an HIV-1 vaccine. Most HIV-1 vaccines target conserved envelope areas. New analyses of the sequence-variable areas of the HIV-1 gp120 envelope glycoprotein have found conserved immunological and structural characteristics. These recombinant immunogens may address HIV-1's antigenic variety and elicit protective antibodies to prevent infection.

Zolla-Pazner, S., & Cardozo, T. (2010). Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design. Nature reviews. Immunology, 10(7), 527–535. https://doi.org/10.1038/nri2801