Short Communication: Manα1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope—Jan 2017

This work investigated how high-mannose glycans conceal conserved V3 crown (GPG) and V2i epitopes on HIV-1 Env's most exposed distal surface's hypervariable loops. We found that Manα1-2Man-binding lectins enhance the exposure of partially and transiently exposed epitopes and increase antibody neutralization strength.

Jan, M., Upadhyay, C., Sharma, A., Hioe, C. E., & Arora, S. K. (2017). Short Communication: Manα1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope. AIDS research and human retroviruses, 33(9), 941–945. https://doi.org/10.1089/AID.2016.0262