SMAD4 Controls Cancer Cell Metabolism by Regulating Methylmalonic Aciduria Cobalamin Deficiency (cbl) B Type. Molecules and cells — SOng, 2022

In this study, the authors investigated the role of SMAD4, a protein known to play a key role in regulating cell growth and differentiation, in cancer cell metabolism. Specifically, they focused on the relationship between SMAD4 and methylmalonic aciduria cobalamin deficiency (cbl) B type, a protein that is involved in the breakdown of certain amino acids and fatty acids. Using a variety of experimental techniques, the authors found that SMAD4 interacts directly with cblB and regulates its expression in cancer cells. They also showed that SMAD4-mediated regulation of cblB is important for the maintenance of cancer cell metabolism, particularly in the breakdown of branched-chain amino acids. Overall, the findings suggest that SMAD4 plays a key role in controlling cancer cell metabolism by regulating the expression of cblB. This could have important implications for the development of new treatments for cancer that target metabolic pathways.

Song K, Lee HS, Jia L, Chelakkot C, Rajasekaran N, Shin YK.  SMAD4 Controls Cancer Cell Metabolism by Regulating Methylmalonic Aciduria Cobalamin Deficiency (cbl) B Type.  Mol. Cells 2022;45:413-424.  https://doi.org/10.14348/molcells.2022.0067