Cell Therapy for Intracranial Aneurysms: A Review— ADibi 2016

Endovascular coiling, the current standard of treatment for treating cerebral aneurysms, results in a recurrence of the aneurysm in one in five patients due to poor healing. The coiling treatment's single significant downside, recurrence, has been the subject of numerous investigations over the past 20 years. Aneurysms may now be treated with cell therapy, a cutting-edge therapeutic approach that involves introducing healing cells to the location of the damage to encourage tissue regeneration. To stop the aneurysm from reoccurring, cell therapy can be used to target the many cellular processes involved in the healing response that follows aneurysm embolization. Between 1999 and 2014, ten preclinical trials using cell therapy to treat aneurysms were reported. We describe the findings of these investigations and talk about the developments, drawbacks, and potential of cell therapy for cerebral aneurysms in this review.

Adibi, A., Sen, A., & Mitha, A. P. (2016). Cell Therapy for Intracranial Aneurysms: A Review. World neurosurgery, 86, 390–398. https://doi.org/10.1016/j.wneu.2015.10.082