Understanding the Genetics of Intracranial Aneurysms: A Primer— Laurent 2022

Intracranial aneurysms have complicated genetics. The extracellular matrix that surrounds the cerebral vasculature and the function of matrix metalloproteinases have both been the subject of extensive research. This extensive analysis critically examines the published findings while summarizing what is now known about the significant genetic factors that lead to aneurysm formation. While taking into account current research's shortcomings, we explore intriguing pre-clinical models of aneurysm formation and subarachnoid hemorrhage and identify potential future research directions. This review will also operate as a thorough reference manual to comprehend the genetic foundations of aneurysm pathophysiology and as a starting point for additional research.

Laurent, D., Small, C., Lucke-Wold, B., Dodd, W. S., Chalouhi, N., Hu, Y. C., Hosaka, K., Motwani, K., Martinez, M., Polifka, A., Koch, M., Busl, K. M., Maciel, C. B., & Hoh, B. (2022). Understanding the genetics of intracranial aneurysms: A primer. Clinical neurology and neurosurgery, 212, 107060. https://doi.org/10.1016/j.clineuro.2021.107060