Imaging in the era of molecular oncology — Ralph, 2008

This paper discusses the use of macroscopic imaging systems, such as computed tomography, magnetic resonance imaging, and ultrasound, in clinical and preclinical settings. High-resolution adaptations of these systems are now available for use in experimental mouse models, allowing for the development of new imaging probes for use in clinical applications. Fluorescence has played a significant role in the development of sophisticated imaging systems, probes, and genetic reporter systems. The paper also highlights the in vivo role of tumor stromal cells in tumor growth and metastasis, based on intravital imaging studies. The use of a common computing platform can help in assembling data obtained from different imaging techniques for early-stage cancer detection, characterization, and real-time treatment.

Weissleder, R., Pittet, M. Imaging in the era of molecular oncology. Nature 452, 580–589 (2008). https://doi.org/10.1038/nature06917