Immunotherapeutic Approaches to Alzheimer's Disease —Monsonego 2003

This is an audio summary of the article "Immunotherapeutic Approaches to Alzheimer's Disease" by Monsonego in 2003. The immune system occasionally may play a significant part in the degenerative process, despite the fact that inflammation and the immune system are not often thought to be mediators of neurodegenerative illnesses like Alzheimer's disease. Furthermore, it is now known that immune system disorders assumed to be neurodegenerative may be helped by the immune system itself. For the treatment of Alzheimer's disease, immunotherapeutic strategies intended to elicit a humoral immune response have recently been created. Human experiments that were inspired by these findings have had both positive and negative outcomes. It has also been demonstrated in animal models that immunotherapy intended to elicit a cellular immune response may be advantageous in treating central nervous system damage, albeit T cells may have either a favorable or unfavorable impact depending on the type of T cell response elicited. These fields offer a fresh way to investigate immune system-based treatments for neurodegenerative illnesses, and they will be covered in this article with an emphasis on Alzheimer's disease. We will also talk about how these methods alter microglia activation, which is crucial for treating such illnesses. This is the end of this informational audio track on "Immunotherapeutic Approaches to Alzheimer's Disease" by Monsonego.

Monsonego, A., & Weiner, H. L. (2003). Immunotherapeutic Approaches to Alzheimer’s Disease. Science, 302(5646), 834–838. https://doi.org/10.1126/science.1088469