Modern analytical techniques in metabolomics analysis — Aihua, 2011

An overview of analytical methods used in metabolomics, the study of small molecules present in biological systems. The authors highlight the importance of metabolomics in understanding biological systems. Highlighting the importance of metabolomics in understanding biological processes and identifying biomarkers for disease diagnosis. Various techniques for metabolite separation and detection, such as gas chromatography, liquid chromatography, and mass spectrometry. Discussing the importance of data preprocessing and statistical analysis in metabolomics studies. Highlights the importance of metabolite identification, which can be challenging due to the large number and diversity of metabolites in biological systems. Discusses various approaches for metabolite identification, such as spectral matching, tandem mass spectrometry, and stable isotope labeling. The most important part is integrating metabolomics data with other omics data (such as genomics and proteomics) to gain a more comprehensive understanding of biological systems. Concluding by emphasizing the need for continued method development and standardization in the field of metabolomics to ensure robust and reproducible results.

Zhang, Aihua, et al. “Modern Analytical Techniques in Metabolomics Analysis.” Analyst, The Royal Society of Chemistry, 21 Nov. 2011, https://doi.org/10.1039/C1AN15605E.