Identifying epitopes of HIV-1 that induce protective antibodies—Zolla-Pazner 2004

Over the past 20 years, HIV-1 vaccine opinion has swung between inducing antibodies or cell-mediated immune responses. An HIV-1 vaccine should induce humoral and cellular immunity for optimum protection, according to current thinking. Inducing widely reactive, powerful antibodies with protective properties has hindered HIV-1 vaccine development. HIV-1 vaccine researchers must define epitopes and construct immunogens to produce these antibodies.

Zolla-Pazner S. (2004). Identifying epitopes of HIV-1 that induce protective antibodies. Nature reviews. Immunology, 4(3), 199–210. https://doi.org/10.1038/nri1307