HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse—VASILIVER-SHAMIS 2010

The virological synapse (VS) is a tight adhesive connection between an HIV-infected cell and an uninfected target cell that efficiently transfers virus without cell-cell fusion. The VS may resemble the immunological synapse (IS). This review article compares IS with VS structurally and highlights VS TCR signaling components. The IS and VS have differing disintegration and intracellular signaling dynamics, which may affect biological effects. Thus, HIV-1 uses IS and TCR signaling components to induce specific changes in cellular shape, motility, and activation that enable its transmission and cell-to-cell dissemination.

Vasiliver-Shamis, G., Dustin, M. L., & Hioe, C. E. (2010). HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse. Viruses, 2(5), 1239–1260. https://doi.org/10.3390/v2051239