The neuropathological diagnosis of Alzheimer’s disease —DeTure 2019

This is an audio summary of the article "The neuropathological diagnosis of Alzheimer’s disease" by DeTure in 2019. Although less prevalent clinical manifestations are gradually identified, Alzheimer's disease is a progressive neurodegenerative illness most frequently linked with memory problems and cognitive decline. The presence of these amyloid plaques and neurofibrillary tangles is still necessary for a clinical diagnosis today despite the fact that the disease's key pathological characteristics have been understood for more than a century. Globally, Alzheimer's disease is the most frequent cause of dementia. For the vast majority of patients, there are still no viable treatment options available, and other than a limited number of family instances caused by genetic abnormalities, the disease's principal causes are still unknown. The knowledge that Alzheimer's disease is a mixed proteinopathy (amyloid and tau) usually coupled with other age-related diseases such as cerebrovascular disease and Lewy body disease complicates efforts to create efficient diagnostic tools and disease-modifying therapeutics. Research is still being done to clarify the connections and interaction of diverse co-pathologies. This article describes the pathologic characteristics of Alzheimer's disease that are associated with etiology as well as those that are unavoidable findings of ambiguous relevance, including granulovacuolar degeneration and Hirano bodies. There is also discussion of additional disease processes that are common but not always present, such as pathologic diseases that can have clinical similarities to Alzheimer's disease. These include argyrophilic grain sickness, TDP-43 proteinopathies, Lewy body disease, and cerebrovascular illness. An overview of the pathophysiology of Alzheimer's disease, its defining pathologic substrates, and the associated pathologies that may have an impact on diagnosis and therapy are provided in this article. This is the end of this informational audio track on "The neuropathological diagnosis of Alzheimer’s disease" by DeTure.

DeTure, M. A., & Dickson, D. W. (2019, August 2). The neuropathological diagnosis of Alzheimer’s disease - Molecular Neurodegeneration. BioMed Central. https://doi.org/10.1186/s13024-019-0333-5